Hydromorphonum [INN-Latin]

Hydromorphonum [INN-Latin] Brand names, Hydromorphonum [INN-Latin] Analogs

Hydromorphonum [INN-Latin] Brand Names Mixture

No information avaliable

Hydromorphonum [INN-Latin] Chemical_Formula

C₁₇H₁₉NO₃

Hydromorphonum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic/hydromorphone.htm

Hydromorphonum [INN-Latin] fda sheet

Hydromorphonum_[INN-Latin] FDA

Hydromorphonum [INN-Latin] msds (material safety sheet)

Hydromorphonum_[INN-Latin] MSDS

Hydromorphonum [INN-Latin] Synthesis Reference

No information avaliable

Hydromorphonum [INN-Latin] Molecular Weight

285.338 g/mol

Hydromorphonum [INN-Latin] Melting Point

266-267 ^oC

Hydromorphonum [INN-Latin] H₂O Solubility

No information avaliable

Hydromorphonum [INN-Latin] State

Solid

Hydromorphonum [INN-Latin] LogP

1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))

Hydromorphonum [INN-Latin] Dosage Forms

Capsule (controlled-delivery); Solution; Tablet

Hydromorphonum [INN-Latin] Indication

For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.

Hydromorphonum [INN-Latin] Pharmacology

Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.

Hydromorphonum [INN-Latin] Absorption

Better absorbed orally than morphine

Hydromorphonum [INN-Latin] side effects and Toxicity

Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.

Hydromorphonum [INN-Latin] Patient Information

http://www.drugs.com/cons/Hydroflumethiazide.html

Hydromorphonum [INN-Latin] Organisms Affected

Humans and other mammals